Caspase-10 Rabbit Polyclonal Antibody (CAB0216)
- SKU:
- CAB0216
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | Caspase-10 Rabbit Polyclonal Antibody |
SKU: | CAB0216 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-521 of human Caspase-10 (NP_116759.2). |
Sequence: | VKTF LEAL PQES WQNK HAGS NGNR ATNG APSL VSRG MQGA SANT LNSE TSTK RAAV YRMN RNHR GLCV IVNN HSFT SLKD RQGT HKDA EILS HVFQ WLGF TVHI HNNV TKVE MEMV LQKQ KCNP AHAD GDCF VFCI LTHG RFGA VYSS DEAL IPIR EIMS HFTA LQCP RLAE KPKL FFIQ ACQG EEIQ PSVS IEAD ALNP EQAP TSLQ DSIP AEAD FLLG LATV PGYV SFRH VEEG SWYI QSLC NHLK KLVP RHED ILSI LTAV NDDV SRRV DKQG TKKQ MPQP AFTL RKKL VFPV PLDA LS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | MCH4; ALPS2; FLICE2; FLICE-2; Caspase-10 |
Positive Sample: | Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, ripoptosome |
Calculated MW: | 59kDa |
Observed MW: | 17kDa |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 843 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |