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Caspase-1 p20 Monoclonal Antibody

SKU:
CAB23429
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

Caspase-1 p20 Monoclonal Antibody (CAB23429)

The Caspase-1 p20 Monoclonal Antibody is a valuable tool for researchers studying inflammatory pathways and cell death mechanisms. This antibody, specifically designed for detecting the p20 subunit of Caspase-1, is ideal for use in Western blot applications and immunohistochemistry.Caspase-1 is a key player in the inflammatory response, as it is responsible for the processing and activation of pro-inflammatory cytokines such as IL-1β and IL-18. The p20 subunit is a crucial part of the active Caspase-1 enzyme, making it a significant target for research aimed at understanding and modulating inflammatory signaling pathways.This monoclonal antibody, developed and validated by AssayGenie, offers high specificity and sensitivity in detecting Caspase-1 p20 in human samples.

Its reliability and consistency make it a valuable tool for scientists investigating the role of Caspase-1 in inflammatory diseases, autoimmune disorders, and other conditions where dysregulated cell death pathways are implicated.Overall, the Caspase-1 p20 Monoclonal Antibody is an essential resource for researchers seeking to unravel the complexities of inflammatory responses and cell death mechanisms, with the ultimate goal of developing targeted therapies for a range of diseases.

Product Name:Caspase-1 p20 Monoclonal Antibody
Product Code:CAB23429
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC60705
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:1000-1:5000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:THP-1, THP-1+TPA+LPS
Cellular Location:Cytoplasm, Cell membrane
Customer Validation:WB(Mus musculus)

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Caspase-1 p20(NP_001244047.1).
Sequence:DVKKN LTASD MTTEL EAFAH RPEHK TSDST FLVFM SHGIR EGICG KKHSE QVPDI LQLNA IFNML NTKNC PSLKD KPKVI IIQAC RGDSP GVVWF KDSVG
Synonyms:ICE, P45, IL1BC
Calculated MW:10KDa/29KDa/35KDa/42KDa/45KDa
Observed MW:20-25kDa

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