The Casp8AP2 Polyclonal Antibody (CAB15770) is a crucial tool for research involving Casp8AP2, a protein known to play a role in regulating apoptosis and inflammation. This antibody, developed using rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the Casp8AP2 protein, researchers can accurately detect and analyze its expression in various cell types, making it a valuable asset for studies in immunology, cancer research, and beyond.Casp8AP2, also known as FLIP2, is a key player in the apoptotic pathway, acting as a regulator of cell death and survival. Its involvement in inflammation signaling pathways makes it a promising target for research into diseases such as cancer, where dysregulation of apoptosis can lead to uncontrolled cell growth.
By delving into the mechanisms behind Casp8AP2 activity, researchers can gain insights into potential therapeutic strategies for combating cancer and other related conditions.In summary, the Casp8AP2 Polyclonal Antibody offers researchers a powerful tool for investigating the functions and implications of Casp8AP2 in various biological processes. Its high reactivity and specificity make it an essential component for studies aimed at unraveling the complexities of cell signaling pathways and developing novel treatments for diseases associated with apoptosis dysregulation.
Product Name:
CASP8AP2 Rabbit Polyclonal Antibody
SKU:
CAB15770
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1733-1982 of human CASP8AP2 (NP_036247.1).
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.
Purification Method:
Affinity purification
Gene ID:
9994
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CASP8AP2 Rabbit pAb (CAB15770) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
