Caspase-5 Polyclonal Antibody (CAB16733)
- SKU:
- CAB16733
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | Caspase-5 Polyclonal Antibody |
SKU: | CAB16733 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant Protein corresponding to a sequence within amino acids 140-250 of human Caspase-5 (NP_001129584). |
Sequence: | QMFT QTLL NMDQ KITS VKPL LQIE AGPP ESAE STNI LKLC PREE FLRL CKKN HDEI YPIK KRED RRRL ALII CNTK FDHL PARN GAHY DIVG MKRL LQGL GYTV VDEK NLT |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | ICH-3; ICEREL-III; ICE(rel)III; Caspase-5 |
Positive Sample: | THP-1,THP-1+TPA+LPS |
Cellular Localization: | cytoplasm, cytosol, NLRP1 inflammasome complex |
Calculated MW: | 50kDa |
Observed MW: | 35kDa/50kDa/44kDa |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
Purification Method: | Affinity purification |
Gene ID: | 838 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |