Caspase-12 Rabbit Polyclonal Antibody (CAB0217)
- SKU:
- CAB0217
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | Caspase-12 Rabbit Polyclonal Antibody |
SKU: | CAB0217 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Caspase-12 (NP_001177945.2). |
Sequence: | FNNR NCQS LKDK PKVI IMQA CRGN GAGI VWFT TDSG KASA DTHG RLLQ GNIC NDAV TKAH VEKD FIAF KSST PHNV SWRH ETNG SVFI SQII YYFR EYSW S |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | CASP-12; CASP12P1; Caspase-12 |
Positive Sample: | Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | AIM2 inflammasome complex, cytoplasm, endoplasmic reticulum, IPAF inflammasome complex, NLRP3 inflammasome complex |
Calculated MW: | 39kDa |
Observed MW: | 55kDa |
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
Purification Method: | Affinity purification |
Gene ID: | 100506742 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |