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Caspase-1 Rabbit Polyclonal Antibody (CAB0964)

SKU:
CAB0964
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-Caspase-1 Antibody CAB0964
  • Cell Death Antibodies 1 Anti-Caspase-1 Antibody CAB0964
  • Cell Death Antibodies 1 Anti-Caspase-1 Antibody CAB0964
  • Cell Death Antibodies 1 Anti-Caspase-1 Antibody CAB0964
  • Cell Death Antibodies 1 Anti-Caspase-1 Antibody CAB0964
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Caspase-1 Rabbit Polyclonal Antibody
SKU:CAB0964
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 201-300 of human Caspase 1 (NP_150634.1).
Sequence:DVKK NLTA SDMT TELE AFAH RPEH KTSD STFL VFMS HGIR EGIC GKKH SEQV PDIL QLNA IFNM LNTK NCPS LKDK PKVI IIQA CRGD SPGV VWFK DSVG
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:1000 - 1:5000 IF/ICC,1:50 - 1:200
Synonyms:ICE; P45; IL1BC; Caspase-1
Positive Sample:HepG2,Hela,Mouse lung,Mouse spleen
Conjugate:Unconjugated
Cellular Localization:Cytoplasm.
Calculated MW:45kDa
Observed MW:45kDa

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Purification Method:Affinity purification
Gene ID:834
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using CASP1 Rabbit pAb (CAB0964) at 1:1800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.

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