CASC5 Rabbit Polyclonal Antibody (CAB13108)
- SKU:
- CAB13108
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | CASC5 Rabbit Polyclonal Antibody |
SKU: | CAB13108 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CASC5 (NP_733468.3). |
Sequence: | MDGV SSEA NEEN DNIE RPVR RRHS SILK PPRS PLQD LRGG NERV QESN ALRN KKNS RRVS FADT IKVF QTES HMKI VRKS EMEG CSAM VPSQ LQLL PPGF KRFS CLSL PETE TGEN LLLI QNKK LEDN YCEI TGMN TLLS APIH TQMQ QKEF SIIE HTRE RKHA NDQT VIFS DENQ MDLT SSHT VMIT KGLL DNPI SEKS TKID TTSF LANL KLHT EDSR MKKE VNFS VDQN TSSE NKID FNDF IKRL KTGK CSAF PDVP DKEN FEIP IYSK EPNS ASST HQMH VSLK EDEN NSNI TRLF |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | D40; CT29; Spc7; CASC5; MCPH4; hKNL-1; AF15Q14; PPP1R55; hSpc105 |
Positive Sample: | HepG2,U-87MG,HeLa,Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, centromere, kinetochore. |
Calculated MW: | 265kDa |
Observed MW: | 300kDa |
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.
Purification Method: | Affinity purification |
Gene ID: | 57082 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |