The CAS3 Polyclonal Antibody (PAC061750) is a valuable tool for researchers studying CAS3, a protein involved in apoptotic cell death signaling pathways. This antibody, generated in rabbits, exhibits high specificity towards CAS3 in human samples and has been validated for use in Western blot applications. By binding to the CAS3 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in apoptosis and cell death mechanisms.CAS3, also known as caspase 3, is a key player in the execution phase of cell apoptosis, a process essential for maintaining tissue homeostasis and eliminating damaged or infected cells.
Dysregulation of CAS3 activity has been linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. Therefore, investigating the role of CAS3 in these pathologies is crucial for developing targeted therapies and diagnostic tools.Overall, the CAS3 Polyclonal Antibody is a reliable reagent for researchers exploring the complex mechanisms underlying apoptotic cell death and its implications in disease pathogenesis. Its high specificity and sensitivity make it a valuable asset in the fields of cell biology, cancer research, and drug discovery.
Antibody Name:
cas3 Antibody (PACO61750)
Antibody SKU:
PACO61750
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Thermus thermophilus
Immunogen:
Recombinant Thermus thermophilus CRISPR-associated endonuclease/helicase Cas3 protein (120-226AA)
Western Blot. Positive WB detected in Recombinant protein. All lanes: cas3 antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 45 kDa. Observed band size: 45 kDa.
Background:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acid,. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity. The N-terminal domain (residues 6-260) acts as a ssDNA endonuclease, has no activity on dsDNA.
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity. The N-terminal domain (residues 6-260) acts as a ssDNA endonuclease, has no activity on dsDNA.
