The Carm1 Polyclonal Antibody (CAB2246) is a valuable tool for researchers studying the protein arginine methyltransferase, Carm1. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the Carm1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in cancer research and epigenetics.Carm1 is known to play a crucial role in gene regulation, specifically in processes such as transcriptional activation and chromatin remodeling.
Dysregulation of Carm1 has been linked to various diseases, including cancer, making it an attractive target for therapeutic interventions. By understanding the function of Carm1, researchers can gain valuable insights into the mechanisms underlying disease development and progression, paving the way for novel treatment strategies.
Product Name:
CARM1 Rabbit Polyclonal Antibody
SKU:
CAB2246
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 486-603 of human PRMT4/CARM1 (NP_954592.1).
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9.
Purification Method:
Affinity purification
Gene ID:
10498
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and PRMT4/CARM1 knockout (KO) 293T cells, using [KO Validated] PRMT4/CARM1 Rabbit pAb (CAB2246) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
