CARD8 Rabbit Polyclonal Antibody (CAB0293)
- SKU:
- CAB0293
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | CARD8 Rabbit Polyclonal Antibody |
SKU: | CAB0293 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CARD8 (NP_003796.1). |
Sequence: | MEAR DKQV LRSL RLEL GAEV LVEG LVLQ YLYQ EGIL TENH IQEI NAQT TGLR KTML LLDI LPSR GPKA FDTF LDSL QEFP WVRE KLKK AREE AMTD LPAG DRLT GIPS HILN SSPS DRQI NQLA QRLG PEWE PMVL SLGL SQTD IYRC KANH PHNV QSQV VEAF IRWR QRFG KQAT FQSL HNGL RAVE VDPS LLLH MLE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL; CARD8 |
Positive Sample: | K-562,A673,ES-2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 61kDa |
Observed MW: | 60kDa |
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 22900 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |