The CARD8 Polyclonal Antibody (CAB0293) is a valuable tool for researchers studying the CARD8 protein, which is involved in innate immune responses and inflammation regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the CARD8 protein, researchers can accurately detect and analyze its expression in various cell types, making it a key player in immunological and cancer research.CARD8, also known as TUCAN (Tumor necrosis factor (TNF) alpha-induced protein 3), is a crucial component in the regulation of immune responses and inflammation.
Understanding the function of CARD8 is essential for unraveling its role in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By targeting CARD8, researchers aim to develop therapies that modulate immune responses and combat diseases associated with dysregulated inflammation. Overall, the CARD8 Polyclonal Antibody (CAB0293) provides researchers with a reliable tool to further their understanding of CARD8's role in immune regulation, paving the way for potential therapeutic interventions in various disease contexts.
Product Name:
CARD8 Rabbit Polyclonal Antibody
SKU:
CAB0293
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CARD8 (NP_003796.1).
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
22900
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CARD8 antibody (CAB0293) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
