The CARD6 Polyclonal Antibody (PACO23636) is a powerful tool for researchers studying the CARD6 protein, a key player in cellular signaling pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the CARD6 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential resource for studies in immunology, inflammation, and cancer research.
CARD6, also known as caspase recruitment domain-containing protein 6, is involved in mediating immune responses and regulating cell death processes. Its importance in signaling cascades makes it a valuable target for investigating diseases such as cancer, autoimmune disorders, and inflammatory conditions. Uncovering the functions of CARD6 is crucial for understanding the mechanisms underlying these diseases and developing targeted therapies that can manipulate immune responses for therapeutic benefit.
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HeLa cells, using CARD6 antibody.
Immunofluorescence analysis of HeLa cells, using CARD6 antibody.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CARD6 antibody.
Background:
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB.
Synonyms:
Caspase recruitment domain-containing protein 6; CARD6;
UniProt Protein Function:
May be involved in apoptosis.
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]
