The CARD18 Antibody (PAC063271) is a highly specific and sensitive tool for researchers studying the CARD18 protein, an essential component of the NF-κB signaling pathway. This polyclonal antibody, produced in rabbits, has been validated for Western blotting applications and demonstrates high reactivity with human samples.CARD18, also known as CARD12, plays a critical role in regulating immune responses and inflammation by modulating NF-κB activation. Dysregulation of this pathway has been implicated in various inflammatory diseases, making CARD18 an attractive target for therapeutic intervention.
By using the PAC063271 antibody, researchers can detect and analyze CARD18 protein levels in different cell types, providing valuable insights into its function in inflammatory signaling pathways. This antibody is a valuable tool for immunology and inflammation research, shedding light on potential therapeutic targets for inflammatory conditions and autoimmune disorders.
Antibody Name:
CARD18 Antibody (PACO63271)
Antibody SKU:
PACO63271
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Caspase recruitment domain-containing protein 18 protein (1-90AA)
IHC image of PACO63271 diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Inhibits generation of IL-1-β by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
Synonyms:
Caspase recruitment domain-containing protein 18 (Caspase-1 inhibitor Iceberg), CARD18, ICEBERG
UniProt Protein Function:
Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
