CARD11 Rabbit Polyclonal Antibody (CAB7140)
- SKU:
- CAB7140
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | CARD11 Rabbit Polyclonal Antibody |
SKU: | CAB7140 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 985-1154 of human CARD11 (NP_115791.3). |
Sequence: | AKTL VQRL LNSG GAME FTIC KSDI VTRD EFLR RQKT ETII YSRE KNPN AFEC IAPA NIEA VAAK NKHC LLEA GIGC TRDL IKSN IYPI VLFI RVCE KNIK RFRK LLPR PETE EEFL RVCR LKEK ELEA LPCL YATV EPDM WGSV EELL RVVK DKIG EEQR KTIW VDED QL |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 |
Synonyms: | PPBL; BENTA; BIMP3; IMD11; CARMA1; IMD11A; CARD11 |
Positive Sample: | Raji,Jurkat,Mouse thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane raft. |
Calculated MW: | 133kDa |
Observed MW: | 133kDa |
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
Purification Method: | Affinity purification |
Gene ID: | 84433 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |