The Carbonic Anhydrase 1 Rabbit Monoclonal Antibody (CAB4406) is a high-quality research tool designed for the detection and analysis of Carbonic Anhydrase 1 (CA1) protein. CA1 is an enzyme involved in the regulation of acid-base balance and is found in various tissues, including the kidneys, lungs, and red blood cells.This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. Its specificity for CA1 enables accurate detection and quantification, making it a valuable tool for studies in physiology, biochemistry, and medicine.The role of CA1 in various physiological processes, such as respiration, acid-base balance, and bone resorption, makes it a crucial target for research into diseases like osteoporosis, renal dysfunction, and certain types of cancer.
Understanding the expression and activity of CA1 can provide insights into the pathophysiology of these conditions and potentially lead to the development of novel diagnostic and therapeutic strategies.Overall, the CAB4406 antibody offers researchers a reliable and sensitive means of studying CA1 protein expression and function in different biological contexts, making it an essential tool for advancing our understanding of human health and disease.
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
759
Clone Number:
ARC1062
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Carbonic Anhydrase 1 (CA1) (CA1) Rabbit mAb (CAB4406) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
