Calpain small subunit 1 Rabbit Polyclonal Antibody (CAB6539)
- SKU:
- CAB6539
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | Calpain small subunit 1 Rabbit Polyclonal Antibody |
SKU: | CAB6539 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 69-268 of human Calpain small subunit 1 (NP_001740.1). |
Sequence: | ISEA AAQY NPEP PPPR THYS NIEA NESE EVRQ FRRL FAQL AGDD MEVS ATEL MNIL NKVV TRHP DLKT DGFG IDTC RSMV AVMD SDTT GKLG FEEF KYLW NNIK RWQA IYKQ FDTD RSGT ICSS ELPG AFEA AGFH LNEH LYNM IIRR YSDE SGNM DFDN FISC LVRL DAMF RAFK SLDK DGTG QIQV NIQE WLQL TMYS |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | CANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4; Calpain small subunit 1 |
Positive Sample: | BT-474,U-251MG,SKOV3,Mouse lung,Mouse heart,Mouse spleen,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm. |
Calculated MW: | 28kDa |
Observed MW: | 28kDa |
This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 826 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |