Calpain small subunit 1 Rabbit Polyclonal Antibody (CAB6539)
The CAPNS1 Polyclonal Antibody (CAB6539) is a valuable tool for researchers studying calpain small subunit 1 (CAPNS1), a protein involved in various cellular processes including cell cycle regulation, signal transduction, and apoptosis. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting CAPNS1 in human samples, making it a reliable option for Western blotting experiments.CAPNS1, a member of the calpain protein family, is known to interact with various proteins and play a role in processes such as cell proliferation and differentiation. Dysregulation of CAPNS1 has been implicated in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases, highlighting its importance in cellular function and disease pathology.
By utilizing the CAPNS1 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of CAPNS1 in different cell types and disease states. This antibody serves as a valuable tool for investigating the molecular mechanisms underlying CAPNS1-related pathologies and may ultimately contribute to the development of targeted therapies for various diseases.
Product Name:
Calpain small subunit 1 Rabbit Polyclonal Antibody
SKU:
CAB6539
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 69-268 of human Calpain small subunit 1 (NP_001740.1).
This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
826
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Calpain small subunit 1 Rabbit pAb (CAB6539) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
