The CAPN9 Polyclonal Antibody (CAB17085) is a valuable tool for researchers studying the calpain-9 protein, which plays a role in cell signaling and apoptosis. This rabbit-derived antibody is highly specific for human samples and has been validated for use in Western blotting applications. By targeting the CAPN9 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in cell biology, signaling pathways, and apoptosis research.Calpain-9 is a member of the calpain family of calcium-dependent proteases, and is involved in various cellular processes such as cell cycle regulation, cytoskeletal remodeling, and apoptosis.
Dysregulation of calpain-9 has been linked to numerous diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Therefore, understanding the function and regulation of calpain-9 is essential for developing targeted therapies and treatments for these conditions.Overall, the CAPN9 Polyclonal Antibody (CAB17085) offers researchers a reliable tool for investigating the role of calpain-9 in cellular processes and disease pathogenesis. Its specificity, sensitivity, and versatility make it a valuable asset for researchers in the fields of cell biology, biochemistry, and molecular biology.
Product Name:
CAPN9 Rabbit Polyclonal Antibody
SKU:
CAB17085
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 391-690 of human CAPN9 (NP_006606.1).
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10753
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human stomach using CAPN9 Rabbit pAb (CAB17085) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
