The CAPN9 Polyclonal Antibody (CAB13782) is a powerful tool for researchers studying the role of CAPN9, a member of the calpain family of intracellular calcium-dependent cysteine proteases. This antibody, generated in rabbits, is highly specific and reacts strongly with human samples, making it ideal for a variety of research applications.CAPN9 is involved in various cellular processes, including cell proliferation, migration, and apoptosis, making it a key player in cancer development and progression. By targeting CAPN9 with this antibody, researchers can effectively detect and analyze the protein in a variety of cell types, providing valuable insights into its function and potential as a therapeutic target.
With its high reactivity and specificity, the CAPN9 Polyclonal Antibody is validated for use in Western blot applications, offering reliable results for studies in cancer biology, signaling pathways, and drug development. By understanding the role of CAPN9 in disease pathogenesis, researchers can uncover new opportunities for targeted therapies and personalized medicine approaches.
Product Name:
CAPN9 Rabbit Polyclonal Antibody
SKU:
CAB13782
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 391-690 of human CAPN9 (NP_006606.1).
SGC-7901,HL-60,HT-29,Mouse stomach,Mouse small intestine,Rat stomach,Rat small intestine
Conjugate:
Unconjugated
Cellular Localization:
cytoplasm
Calculated MW:
79kDa
Observed MW:
79kDa
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10753
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CAPN9 Rabbit pAb (CAB13782) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
