The CAPN7 Polyclonal Antibody (CAB17666) is a valuable tool for researchers studying CAPN7, a member of the calpain family of calcium-dependent proteases. This antibody, generated in rabbits, is highly specific for detecting CAPN7 in human samples and is validated for use in Western blot applications. By binding to the CAPN7 protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for studies in molecular biology and cell biology research.CAPN7 is known for its involvement in cellular processes such as protein degradation, cytoskeletal remodeling, and signal transduction. Its role in regulating cell proliferation, differentiation, and apoptosis highlights its significance in various physiological and pathological conditions.
Researchers studying cancer, neurodegenerative disorders, and cardiovascular diseases can benefit from understanding the function of CAPN7 and its potential as a therapeutic target.By utilizing the CAPN7 Polyclonal Antibody (CAB17666), researchers can gain valuable insights into the role of CAPN7 in cellular processes and disease pathogenesis. This antibody provides a reliable tool for investigating the molecular mechanisms underlying CAPN7 function, ultimately paving the way for the development of novel therapeutic strategies targeting this important protease.
Product Name:
CAPN7 Rabbit Polyclonal Antibody
SKU:
CAB17666
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-220 of human CAPN7 (NP_055111.1).
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity.
Purification Method:
Affinity purification
Gene ID:
23473
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells, using CAPN7 Rabbit pAb (CAB17666) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
