The CAPN12 Antibody (PACO6313) is a polyclonal antibody designed for research involving CAPN12, a member of the calpain small subunit family that plays a role in calcium-dependent intracellular processes. Raised in rabbits, this antibody is highly reactive with human samples and is validated for use in various applications, including Western blotting. By binding specifically to the CAPN12 protein, this antibody enables detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and cell signaling research.CAPN12 is known for its involvement in cellular processes such as protein degradation, cell migration, and cell cycle regulation.
Understanding the functions and mechanisms of CAPN12 is important for unraveling its role in physiological and pathological conditions, including cancer progression, neurodegenerative diseases, and cardiovascular disorders. The CAPN12 Antibody provides a valuable tool for researchers to investigate the molecular pathways and interactions associated with CAPN12, paving the way for potential therapeutic interventions targeting this protein.
Antibody Name:
CAPN12 Antibody (PACO06313)
Antibody SKU:
PACO06313
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human Calpain 12.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of 293 NIH-3T3 A549 K562 cells using Calpain 12 Polyclonal Antibody.
Western Blot analysis of 293 cells using Calpain 12 Polyclonal Antibody.
CAPN12: Calcium-regulated non-lysosomal thiol-protease. Belongs to the peptidase C2 family.Protein type: EC 3.4.22.-; ProteaseChromosomal Location of Human Ortholog: 19q13.2Cellular Component: cytoplasmMolecular Function: calcium-dependent cysteine-type endopeptidase activity; calcium ion bindingBiological Process: proteolysis
UniProt Protein Details:
NCBI Summary:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]
