The CAPN11 Polyclonal Antibody (PAC02217) is a valuable tool for researchers studying CAPN11, a member of the calpain family of intracellular calcium-dependent cysteine proteases. This antibody is produced in rabbits and demonstrates high reactivity with human samples, making it suitable for a range of research applications, including Western blot analysis.CAPN11 is known to be involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of CAPN11 has been linked to several diseases, making it a promising target for therapeutic interventions. By using the CAPN11 Polyclonal Antibody, researchers can detect and analyze CAPN11 protein levels in different cell types, aiding in the investigation of its roles in cancer, neurodegenerative disorders, and other pathological conditions.
Furthermore, understanding the mechanisms by which CAPN11 functions can provide insights into its potential as a biomarker for disease diagnosis or prognosis, as well as a target for developing novel treatments. The CAPN11 Polyclonal Antibody offers researchers a reliable and specific tool to advance their studies in the field of molecular biology and disease research.
Antibody Name:
CAPN11 Antibody (PACO22217)
Antibody SKU:
PACO22217
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human CAPN11.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HepG2 cells, Jurkat cells and HuvEc cells, using CAPN11 antibody.
Background:
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
CAPN11: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Belongs to the peptidase C2 family.Protein type: EC 3.4.22.-; ProteaseChromosomal Location of Human Ortholog: 6p12Cellular Component: acrosomeMolecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; peptidase activityBiological Process: proteolysis
UniProt Protein Details:
NCBI Summary:
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]
