The CAPN11 Polyclonal Antibody (PACO08170) is a valuable tool for researchers studying CAPN11, a calcium-dependent cysteine protease known to be involved in various physiological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been extensively validated for use in Western blot applications.CAPN11 is a key player in the regulation of cellular processes, including cell signaling, apoptosis, and protein degradation. Its dysregulation has been implicated in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases.
By targeting CAPN11 with this antibody, researchers can gain valuable insights into its functions and potential therapeutic applications.With its ability to specifically bind to the CAPN11 protein, this antibody enables precise detection and analysis of CAPN11 in different cell types, providing a versatile tool for studies in various fields, including biochemistry, cell biology, and medicine. By understanding the role of CAPN11 in health and disease, researchers can pave the way for new treatment strategies and therapeutic interventions.
CAPN11: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Belongs to the peptidase C2 family.Protein type: EC 3.4.22.-; ProteaseChromosomal Location of Human Ortholog: 6p12Cellular Component: acrosomeMolecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; peptidase activityBiological Process: proteolysis
UniProt Protein Details:
NCBI Summary:
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]
