The CAPN11 Antibody (PACO00502) is a high-quality polyclonal antibody designed for research involving calpain 11 (CAPN11), a member of the calpain family of calcium-dependent proteases. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it a valuable tool for studying the role of CAPN11 in various biological processes.CAPN11 is known to be involved in numerous cellular functions, including cell signaling, cytoskeletal remodeling, and apoptosis. It is also implicated in diseases such as cancer, cardiovascular disorders, and neurodegenerative diseases.
The CAPN11 antibody is validated for use in Western blot applications, enabling detection and analysis of CAPN11 protein levels in different cell types and tissues.Researchers in the fields of cell biology, biochemistry, and molecular biology will find the CAPN11 Antibody to be a valuable asset in their studies. By elucidating the function of CAPN11 and its potential implications in disease pathology, this antibody can contribute to the development of novel therapeutic strategies targeting the calpain protease family.
Antibody Name:
CAPN11 Antibody
Antibody SKU:
PACO00502
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human Calpain 11.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
CAPN11: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Belongs to the peptidase C2 family.Protein type: EC 3.4.22.-; ProteaseChromosomal Location of Human Ortholog: 6p12Cellular Component: acrosomeMolecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; peptidase activityBiological Process: proteolysis
UniProt Protein Details:
NCBI Summary:
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]
