The CANX Polyclonal Antibody (CAB15631) is a valuable tool for researchers studying CANX, a key protein involved in regulating cellular processes such as protein folding and calcium homeostasis. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CANX protein, this antibody enables researchers to detect and analyze CANX expression in a variety of cell types, making it ideal for studies in cell biology and disease mechanisms.CANX, also known as calnexin, plays a crucial role in protein quality control within the endoplasmic reticulum and is essential for proper folding of glycoproteins.
Dysregulation of CANX has been linked to various diseases, including cancer, neurodegenerative disorders, and diabetes. By studying the function of CANX, researchers can gain insight into the mechanisms underlying these diseases and potentially develop targeted therapies to combat them.Overall, the CANX Polyclonal Antibody is a valuable tool for researchers investigating the role of CANX in cellular processes and disease progression. Its high specificity and reactivity make it a reliable choice for Western blot analysis and other research applications in the fields of cell biology and molecular biology.
Product Name:
Calnexin Rabbit Polyclonal Antibody
SKU:
CAB15631
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-592 of human Calnexin (NP_001737.1).
Endoplasmic reticulum, Endoplasmic reticulum membrane, Melanosome, Single-pass type I membrane protein.
Calculated MW:
68kDa
Observed MW:
90kDa
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
821
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Calnexin Rabbit pAb (CAB15631) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
