CAND1 Rabbit Polyclonal Antibody (CAB14287)
- SKU:
- CAB14287
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | CAND1 Rabbit Polyclonal Antibody |
SKU: | CAB14287 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-980 of human CAND1 (NP_060918.2). |
Sequence: | GALS AMLD FFQA LVVT GTNN LGYM DLLR MLTG PVYS QSTA LTHK QSYY SIAK CVAA LTRA CPKE GPAV VGQF IQDV KNSR STDS IRLL ALLS LGEV GHHI DLSG QLEL KSVI LEAF SSPS EEVK SAAS YALG SISV GNLP EYLP FVLQ EITS QPKR QYLL LHSL KEII SSAS VVGL KPYV ENIW ALLL KHCE CAEE GTRN VVAE CLGK LTLI DPET LLPR LKGY LISG SSY |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | TIP120; TIP120A; CAND1 |
Positive Sample: | HeLa,Mouse brain,Mouse heart,Mouse kidney,Mouse liver,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 136kDa |
Observed MW: | 136kDa |
This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 55832 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |