The CAMTA1 Monoclonal Antibody (PAC019384) is a crucial tool for researchers studying CAMTA1, a transcription factor implicated in various cellular processes, including gene regulation and stress responses. This antibody, produced in a monoclonal mouse host, exhibits high specificity for human samples and is recommended for use in applications such as immunofluorescence and immunohistochemistry.CAMTA1, also known as calmodulin-binding transcription activator 1, plays a pivotal role in controlling gene expression in response to calcium signaling, making it a key player in neuronal development and gene regulation in plants.
Its involvement in these processes suggests its potential importance in research related to neuroscience, developmental biology, and plant science.By targeting CAMTA1 with this specific antibody, researchers can accurately detect and analyze the protein in various cell types and tissues, offering valuable insights into its function and potential as a therapeutic target. This antibody is a valuable tool for advancing our understanding of CAMTA1 and its role in diverse biological processes.
Antibody Name:
CAMTA1 Antibody (PACO19384)
Antibody SKU:
PACO19384
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:15-1:50
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human CAMTA1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO19384(CAMTA1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19384(CAMTA1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Calmodulin-binding transcription activator 1 is a protein that in humans is encoded by the CAMTA1 gene. Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells.
Synonyms:
calmodulin binding transcription activator 1
UniProt Protein Function:
Transcriptional activator. May act as a tumor suppressor.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a CG1 DNA-binding domain, a transcription factor immunoglobulin domain, ankyrin repeats, and calmodulin-binding IQ motifs. The encoded protein is thought to be a transcription factor and may be a tumor suppressor. However, a translocation event is sometimes observed between this gene and the WWTR1 gene, with the resulting WWTR1-CAMTA1 oncoprotein leading to epithelioid hemangioendothelioma, a malignant vascular cancer. [provided by RefSeq, Mar 2017]
