The CAMLG Polyclonal Antibody (CAB13720) is a valuable tool for research on CAMLG, a protein involved in immune regulation and cell signaling pathways. This antibody, produced in rabbits, is highly specific for detecting CAMLG in human samples and is suitable for use in Western blot applications. By binding to CAMLG, researchers can study its function and expression levels in various cell types, aiding in investigations related to immune system regulation and potentially leading to insights into disease mechanisms.CAMLG, also known as calcium signal-modulating cyclophilin ligand, is known to play a role in calcium signaling and immune responses, making it a promising target for research on autoimmune diseases, inflammation, and cancer.
By studying the function of CAMLG, researchers may uncover new strategies for therapeutic interventions and personalized medicine approaches in these disease areas.Overall, the CAMLG Polyclonal Antibody (CAB13720) offers researchers a valuable tool for studying the role of CAMLG in immune regulation and disease pathways, opening doors to potential new treatments and diagnostic strategies in the future.
Product Name:
CAMLG Rabbit Polyclonal Antibody
SKU:
CAB13720
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human CAMLG (NP_001736.1).
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
Purification Method:
Affinity purification
Gene ID:
819
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CAMLG Rabbit pAb (CAB13720) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
