The CAMK2N1 Polyclonal Antibody (PAC063627) is a vital tool for researchers studying the CAMK2N1 protein, which plays a key role in regulating calcium/calmodulin-dependent protein kinase II (CAMKII) activity. This antibody, generated in rabbits, exhibits high specificity towards human samples and has been validated for use in Western blot applications.CAMK2N1 is an important regulator of CAMKII, a protein kinase involved in various cellular processes such as learning, memory, and neuronal signaling.
Dysregulation of CAMKII activity has been associated with neurological disorders and cancer, making CAMK2N1 a promising target for further study in these areas.By targeting the CAMK2N1 protein, researchers can gain valuable insights into the mechanisms underlying CAMKII regulation and its impact on cellular function. The CAMK2N1 Polyclonal Antibody is an essential tool for investigations in neuroscience, cancer biology, and other fields where CAMKII activity is of interest.
Antibody Name:
CAMK2N1 Antibody (PACO63627)
Antibody SKU:
PACO63627
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Peptide sequence from Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 protein (9-27AA)
Immunofluorescence staining of HepG2 cells with PACO63627 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Potent and specific inhibitor of CaM-kinase II (CAMK2).
Synonyms:
Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CaMKII inhibitory protein alpha) (CaMKIIN-alpha), CAMK2N1
UniProt Protein Function:
CAMK2N1: Potent and specific inhibitor of CaM-kinase II (CAMK2). Belongs to the CAMK2N family.Protein type: Inhibitor; Protein kinase, regulatory subunitChromosomal Location of Human Ortholog: 1p36.12Cellular Component: postsynaptic membrane; cell soma; postsynaptic density; dendrite; cell junctionMolecular Function: calcium-dependent protein kinase inhibitor activity; protein kinase bindingBiological Process: negative regulation of protein kinase activity
