The CAMK2G/CAMK2B Antibody (PAC021838) is a high-quality polyclonal antibody designed for researchers studying CAMK2G and CAMK2B proteins. These proteins are key players in cellular signaling pathways, particularly in the regulation of calcium-dependent processes and neuronal activity. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. It binds to the CAMK2G and CAMK2B proteins, allowing for their detection and analysis in various cell types. The CAMK2G/CAMK2B Antibody is essential for studies in neurobiology, cell signaling, and molecular biology.
Understanding the functions and interactions of CAMK2G and CAMK2B proteins can shed light on various physiological and pathological processes, making this antibody a valuable tool for research in neuroscience, cardiovascular biology, and cancer biology. Overall, the CAMK2G/CAMK2B Antibody is a reliable reagent for scientists investigating the roles of CAMK2G and CAMK2B proteins in health and disease, providing insights that could lead to the development of therapeutic strategies targeting these proteins.
Antibody Name:
CAMK2G/CAMK2B Antibody (PACO21838)
Antibody SKU:
PACO21838
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from C-terminal of human CaMK2 β / γ .
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Tombes R.M., Biochim. Biophys. Acta 1355:281-292(1997).
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells and COLO205 cells, using CaMK2 beta / gamma antibody.
Synonyms:
Calcium/calmodulin-dependent protein kinase type II γ chain; EC 2.7.11.17; CaM-kinase II γ chain; CaM kinase II subunit gamma; CaMK-II subunit gamma
UniProt Protein Function:
CAMK2G: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.17; Protein kinase, CAMK; CAMK group; CAMK2 family
Molecular Function:calmodulin binding; protein binding; protein homodimerization activity; calcium-dependent protein serine/threonine phosphatase activity; calmodulin-dependent protein kinase activity; ATP binding
Biological Process: nervous system development; synaptic transmission; dephosphorylation; regulation of skeletal muscle adaptation; insulin secretion; calcium ion transport; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; regulation of calcium ion transport; cell differentiation; protein oligomerization; G1/S transition of mitotic cell cycle
