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CAMK2G/CAMK2B Antibody (PACO00505)

SKU:
PACO00505
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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CAMK2G/CAMK2B Antibody (PACO00505)

The CAMK2G/CAMK2B Antibody (PACO00505) is a polyclonal antibody designed for research involving CAMK2G and CAMK2B, two important proteins in the CAMK2 family that play crucial roles in intracellular calcium signaling pathways. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot and immunohistochemistry applications.CAMK2G and CAMK2B are calcium/calmodulin-dependent protein kinases that regulate various cellular processes such as cell proliferation, gene expression, and neuronal signaling.

Dysregulation of these proteins has been linked to diseases like cancer, neurodegenerative disorders, and cardiovascular diseases, making them promising targets for therapeutic interventions.By enabling the detection and analysis of CAMK2G and CAMK2B in various cell types, the CAMK2G/CAMK2B Antibody provides researchers with valuable insights into the role of these proteins in health and disease. Its high specificity and sensitivity make it a valuable tool for studies in cell biology, neuroscience, and drug discovery focused on calcium signaling pathways.

Antibody Name:CAMK2G/CAMK2B Antibody
Antibody SKU:PACO00505
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the C-terminal region of human CaMKIIBeta/gamma.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CAMK2G; CAMK; CAMK-II; CAMKG; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; CaMK-II subunit gamma; CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit bet
UniProt Protein Function:CAMK2G: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.17; Protein kinase, CAMK; CAMK group; CAMK2 family

Chromosomal Location of Human Ortholog: 10q22

Cellular Component: nucleoplasm; sarcoplasmic reticulum membrane; membrane; plasma membrane; cytosol

Molecular Function:calmodulin binding; protein binding; protein homodimerization activity; calcium-dependent protein serine/threonine phosphatase activity; calmodulin-dependent protein kinase activity; ATP binding

Biological Process: nervous system development; synaptic transmission; dephosphorylation; regulation of skeletal muscle adaptation; insulin secretion; calcium ion transport; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; regulation of calcium ion transport; cell differentiation; protein oligomerization; G1/S transition of mitotic cell cycle

UniProt Code:Q13555
NCBI GenInfo Identifier:62512173
NCBI Gene ID:
NCBI Accession:Q13555.3
UniProt Secondary Accession:Q13555,Q13554,
Molecular Weight:~ 50~80kDa
NCBI Full Name:Calcium/calmodulin-dependent protein kinase type II subunit gamma
UniProt Protein Name:Calcium/calmodulin-dependent protein kinase type II subunit gamma
Protein Family:Calcium/calmodulin-dependent protein kinase
UniProt Gene Name:CAMK2G  
UniProt Entry Name:KCC2G_HUMAN

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