The CAMKII Polyclonal Antibody (CAB0186) is a valuable tool for researchers studying CAMKII, a crucial protein involved in signal transduction and synaptic plasticity. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for various applications, including Western blotting and immunohistochemistry.CAMKII, also known as calcium/calmodulin-dependent protein kinase II, plays a pivotal role in neuronal signaling and memory formation.
Dysregulation of CAMKII has been linked to various neurological disorders, making it a promising therapeutic target for conditions like Alzheimer's disease and epilepsy. By using the CAMKII Polyclonal Antibody, researchers can explore the function and regulation of this protein in different cellular contexts, advancing our understanding of its role in health and disease.
Product Name:
CaMKII Rabbit Monoclonal Antibody
SKU:
CAB0186
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CaMK2 delta/CAMK2 gamma (Q13554).
cytoplasm, cytosol, microtubule organizing center, nucleoplasm
Calculated MW:
73kDa
Observed MW:
50kDa/60kDa
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
817/818
Clone Number:
ARC53334
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CaMK2 delta/CAMK2 gamma Rabbit mAb (CAB0186) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
