Calpain small subunit 1 Rabbit Monoclonal Antibody (CAB8859)
The Calpain Small Subunit 1 Rabbit Monoclonal Antibody (CAB8859) is a valuable tool for researchers studying calpain small subunit 1, a protein involved in various cellular processes including cell migration, apoptosis, and signal transduction. This antibody, produced using rabbit monoclonal technology, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications.Calpain small subunit 1 is a key regulatory component of the calpain protease system, which plays a role in protein degradation and cell signaling pathways. Dysregulation of calpain small subunit 1 has been implicated in various diseases, including neurodegenerative disorders and cancer.
By targeting this protein with CAB8859, researchers can investigate its functions and potential therapeutic implications in these disease contexts.With its high specificity and sensitivity, the Calpain Small Subunit 1 Rabbit Monoclonal Antibody (CAB8859) is a valuable tool for scientists conducting experiments in cell biology, biochemistry, and molecular biology. Its ability to detect and analyze calpain small subunit 1 in various cell types makes it an essential reagent for studies aiming to elucidate the role of this protein in health and disease.
Product Name:
Calpain small subunit 1 Rabbit Monoclonal Antibody
SKU:
CAB8859
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human Calpain small subunit 1 (P04632).
CANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4; Calpain small subunit 1
Positive Sample:
293T,A-549,Mouse brain,Rat lung
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Cytoplasm.
Calculated MW:
28kDa
Observed MW:
28kDa
This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
826
Clone Number:
ARC1326
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Calpain small subunit 1 Rabbit mAb (CAB8859) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
