The Calpain-1 Polyclonal Antibody is a valuable tool for researchers studying calpain-1, a calcium-dependent protease involved in various cellular processes such as cell migration, apoptosis, and signal transduction. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to calpain-1, researchers can detect and analyze the protein in a variety of cell types, making it ideal for studies in cell biology, neuroscience, and cancer research.Calpain-1 is known to play a crucial role in cellular physiology, including cytoskeletal remodeling, protein degradation, and cell proliferation.
Dysregulation of calpain-1 activity has been implicated in various diseases such as muscular dystrophy, neurodegenerative disorders, and cancer. Therefore, understanding the function and regulation of calpain-1 is essential for developing therapeutic strategies targeting this protease in disease intervention and treatment. The Calpain-1 Polyclonal Antibody provides researchers with a valuable tool to investigate the role of calpain-1 in health and disease, advancing our understanding of its potential as a therapeutic target.
Product Name:
Calpain 1 Polyclonal Antibody
SKU:
CAB21673
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-330 of human Calpain 1 (NP_005177.2).
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
823
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Calpain 1 Rabbit pAb (CAB21673) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
