The Calnexin Rabbit Monoclonal Antibody (CAB4846) is a powerful tool for researchers studying calnexin, a key protein involved in protein folding and quality control in the endoplasmic reticulum. This antibody, developed using innovative rabbit monoclonal technology, specifically recognizes calnexin in human samples and is validated for use in Western blot and immunofluorescence applications.Calnexin plays a vital role in maintaining protein homeostasis and ensuring proper folding of newly synthesized proteins in the ER. Dysregulation of calnexin function has been linked to various diseases, including diabetes, neurodegenerative disorders, and cancer.
By targeting calnexin with this high-quality antibody, researchers can investigate its role in protein quality control mechanisms and its impact on disease pathology.With its high specificity and sensitivity, the Calnexin Rabbit Monoclonal Antibody (CAB4846) is an essential tool for scientists conducting research in cell biology, molecular biology, and protein quality control. By enabling precise detection and analysis of calnexin in various cell types and tissues, this antibody contributes to advancing our understanding of protein folding processes and their implications for human health.
Product Name:
Calnexin Rabbit Monoclonal Antibody
SKU:
CAB4846
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 493-592 of human Calnexin (P27824).
Endoplasmic reticulum, Endoplasmic reticulum membrane, Melanosome, Single-pass type I membrane protein.
Calculated MW:
68kDa
Observed MW:
90kDa
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
821
Clone Number:
ARC0648
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Calnexin Rabbit mAb (CAB4846) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
