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Calnexin Polyclonal Antibody

SKU:
CAB24433
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€359
Frequently bought together:

Description

Calnexin Polyclonal Antibody (CAB24433)

The Calnexin Polyclonal Antibody is a valuable tool for researchers studying the protein calnexin, which is involved in protein folding and quality control in the endoplasmic reticulum. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to calnexin, this antibody allows for the detection and analysis of this essential protein in a variety of cell types.Calnexin plays a crucial role in the folding and processing of glycoproteins, ensuring that they are correctly folded before being transported to their final destination within the cell. Dysregulation of calnexin function has been implicated in numerous diseases, including cancer and neurodegenerative disorders.

By studying the activity of calnexin, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets. The Calnexin Polyclonal Antibody is an essential tool for scientists investigating the function of calnexin and its role in protein quality control. Its high specificity and sensitivity make it ideal for a wide range of research applications, from basic protein biology to drug discovery. By using this antibody, researchers can further our understanding of calnexin and its implications for human health.

Product Name:Calnexin Polyclonal Antibody
Product Code:CAB24433
Reactivity:Human, Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:PANC-1, NIH/3T3, Rat spleen
Cellular Location:Endoplasmic reticulum, Endoplasmic reticulum membrane, Melanosome, Single-pass type I membrane protein

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding different isoforms have been described.

Immunogen:KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Calnexin.
Sequence:Email for sequence
Synonyms:CNX, P90, IP90
Calculated MW:68kDa
Observed MW:90kDa

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