The CALM2 Polyclonal Antibody (CAB8008) is a valuable tool for researchers studying CALM2, a calcium-binding protein essential for various cellular processes, including muscle contraction, synaptic transmission, and cell proliferation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the CALM2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in cell biology and neuroscience. CALM2, also known as calmodulin, is a key regulator of calcium signaling in cells and plays a critical role in controlling numerous cellular functions.
Dysregulation of CALM2 has been implicated in various diseases, including cardiovascular disorders, neurodegenerative conditions, and cancer. Studying the function and expression of CALM2 is crucial for gaining insights into the underlying mechanisms of these diseases and for developing potential therapeutic interventions. In summary, the CALM2 Polyclonal Antibody (CAB8008) offers researchers a reliable tool for investigating the functions of CALM2 in health and disease, paving the way for advancements in biomedical research and the development of novel treatment strategies.
Product Name:
CALM2 Rabbit Polyclonal Antibody
SKU:
CAB8008
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human CALM2 (NP_001734.1).
Sequence:
MADQ LTEE QIAE FKEA FSLF DKDG DGTI TTKE LGTV MRSL GQNP TEAE LQDM INEV DADG NGTI DFPE FLTM MARK MKDT DSEE EIRE AFRV FDKD GNGY ISAA ELRH VMTN LGEK LTDE EVDE MIRE ADID GDGQ VNYE EFVQ MMTA K
This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
805
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CALM2 antibody (CAB8008) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (AbGn00020)._Exposure time: 30s.
