The CALCRL Polyclonal Antibody (CAB8533) is a powerful tool for researchers studying CALCRL, a receptor involved in cardiovascular and neurological functions. This antibody is produced in rabbits and is highly specific to human samples, making it an ideal choice for Western blot applications. By binding to CALCRL, this antibody allows for precise detection and analysis in a variety of cell types, making it a valuable asset for studies in cardiology, neurology, and vascular biology.CALCRL, also known as calcitonin gene-related peptide receptor-like receptor, plays a crucial role in vasodilation, pain transmission, and neurotransmitter release. Its involvement in these processes makes it a key target for research into cardiovascular diseases, migraine headaches, and neuronal disorders.
By elucidating the mechanisms of action of CALCRL, researchers can uncover potential therapeutic strategies for addressing these conditions and improving patient outcomes.Overall, the CALCRL Polyclonal Antibody (CAB8533) offers researchers a reliable tool for investigating the functions and regulation of CALCRL in various physiological and pathological contexts. Its high specificity and reactivity make it an essential component of any study aiming to understand the complex roles of CALCRL in health and disease.
Product Name:
CALCRL Rabbit Polyclonal Antibody
SKU:
CAB8533
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 346-445 of human CALCRL (NP_005786.1).
Sequence:
PGYS HDCP SEHL NGKS
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
CRLR; CGRPR; LMPHM8; CALCRL
Positive Sample:
A-549,MCF7,Mouse kidney,Mouse liver,Rat liver
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Multi-pass membrane protein.
Calculated MW:
53kDa
Observed MW:
43kDa
Enables adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in endoplasmic reticulum; endosome; and lysosome. Part of CGRP receptor complex and adrenomedullin receptor complex. Colocalizes with plasma membrane. Implicated in hereditary lymphedema.
Purification Method:
Affinity purification
Gene ID:
10203
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CALCRL antibody (CAB8533) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
