The CALCR Polyclonal Antibody (CAB10006) is a valuable tool for researchers studying the role of CALCR, a cell surface receptor involved in calcium regulation and signaling pathways. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the CALCR protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for studies in molecular biology and physiology.CALCR, also known as calcitonin receptor, is a key player in calcium homeostasis and bone metabolism. Its ability to bind with calcitonin and other ligands makes it a crucial component in regulating calcium levels and bone remodeling.
Researchers studying conditions such as osteoporosis, hypercalcemia, and bone cancer can benefit from using this antibody to explore the role of CALCR in disease pathology and potential therapeutic interventions.Overall, the CALCR Polyclonal Antibody is a reliable reagent for investigating the function and expression of CALCR in both normal physiological processes and disease states. Its specificity and sensitivity make it a valuable asset for researchers looking to further understand the complex mechanisms of calcium regulation and bone health.
Product Name:
CALCR Polyclonal Antibody
SKU:
CAB10674
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-148 of human CALCR (NP_001733.1).
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
799
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CALCR Rabbit pAb (CAB10674) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
