The Calcipressin-1 Polyclonal Antibody (CAB5326) is a valuable tool for researchers studying Calcipressin-1, a protein involved in the regulation of calcium homeostasis and cell signaling pathways. This antibody, produced in rabbits, demonstrates high specificity and reactivity with human samples, making it suitable for use in Western blot applications.Calcipressin-1, also known as RCAN1, is a key regulator of cellular responses to changes in calcium levels, playing a critical role in various physiological processes such as neuronal function, cardiac development, and immune response. Dysregulation of Calcipressin-1 has been implicated in conditions such as Alzheimer's disease, cardiovascular disorders, and diabetes, making it an important target for further research and therapeutic development.
By utilizing the Calcipressin-1 Polyclonal Antibody, researchers can accurately detect and analyze Calcipressin-1 protein expression in different cell types and tissues, providing valuable insights into its role in health and disease. This antibody is a valuable tool for studies in molecular biology, cell signaling, and therapeutic targeting of Calcipressin-1 for potential treatment strategies.
Product Name:
RCAN1 Rabbit Polyclonal Antibody
SKU:
CAB5326
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 60-245 of human RCAN1 (NP_004405.3).
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1827
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using RCAN1 Rabbit pAb (CAB5326) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
