The Calca Polyclonal Antibody (CAB5542) is a key tool for researchers studying the role of the Calca gene, which encodes for the Calcitonin/CGRP family of peptides. This antibody, produced in rabbits, is highly specific to human Calca samples and is validated for use in applications such as immunohistochemistry and ELISA.The Calca gene is known to play a crucial role in regulating calcium homeostasis and is involved in numerous physiological processes, including bone metabolism and pain perception. Aberrant expression of Calca has been implicated in a variety of diseases, making it a promising target for therapeutic interventions.
With its high reactivity and specificity, the Calca Polyclonal Antibody enables researchers to accurately detect and quantify Calca expression in various tissues and cell types. By elucidating the functions of the Calca gene, scientists can advance our understanding of disease mechanisms and potentially identify novel treatment strategies for conditions related to calcium metabolism and pain regulation.
Product Name:
CGRP Rabbit Polyclonal Antibody
SKU:
CAB5542
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 49-128 of human CGRP (NP_001029125.1).
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
796
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with CGRP using CGRP Rabbit pAb(CAB5542) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
