The CALCA Polyclonal Antibody (CAB13957) is a vital tool for researchers studying the CALCA gene, which encodes a precursor protein that is processed into calcitonin and calcitonin gene-related peptide (CGRP). This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in various applications, including Western blot, immunohistochemistry, and ELISA.CALCA, a neuropeptide hormone, plays significant roles in calcium metabolism, bone formation, pain transmission, and cardiovascular regulation. Dysregulation of CALCA expression has been linked to conditions such as osteoporosis, migraine, and cardiovascular diseases.
Therefore, understanding the function and regulation of CALCA is crucial for developing targeted therapies and diagnostic tools for these diseases.The CALCA Polyclonal Antibody enables the detection and analysis of CALCA protein expression in tissues and cells, allowing researchers to investigate its role in physiological processes and diseases. Its specificity and reliability make it an essential tool for studies in neuroscience, endocrinology, and drug development.
Product Name:
CALCA Polyclonal Antibody
SKU:
CAB13957
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-141 of human CALCA (NP_001029124.1).
293T transfected with CALCA,Mouse brain,Rat brain,Rat lung
Conjugate:
Unconjugated
Cellular Localization:
Secreted.
Calculated MW:
13kDa/15kDa
Observed MW:
14kDa
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
796
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using CALCA Rabbit pAb (CAB13957) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
