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Anti-CALCA Antibody (MACO0553)

SKU:
MACO0553
Product Type:
Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Monoclonal Antibody
Conjugation:
Unconjugated
€379
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Description

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Anti-CALCA Antibody (MACO0553)

The CALCA Monoclonal Antibody (MACO0553) is a specialized tool for researchers studying the CALCA gene, which encodes the prohormone calcitonin. This antibody, generated from mouse hybridoma cells, has high specificity and sensitivity for detecting CALCA protein in samples from various species, making it a valuable asset for studies in endocrinology and neuroscience.CALCA is a crucial player in calcium homeostasis, as it regulates calcium levels in the body through its role in bone remodeling and calcium metabolism.

Dysregulation of CALCA has been linked to conditions such as osteoporosis and hypercalcemia, making it a target for therapeutic interventions. By using the MACO0553 antibody, researchers can explore the expression and function of CALCA in different tissues and physiological processes, enhancing our understanding of its involvement in health and disease.

Product Name:Anti-CALCA Antibody
Product Sku:MACO0553
Size:50ug
Host Species:Mouse
Tested Applications:ELISA, IHC
Recommended Dilutions:IHC:1:50-1:500
Species Reactivity:Human
Immunogen:Recombinant Human PCT
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%,Protein G purified
Clonality:Monoclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:
Synonyms:PCT
Product ImageImmunohistochemical of paraffin-embedded human thyroid tissues using MACO0553 at dilution of 1:200
UniProt Protein Function:CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.2

Cellular Component: extracellular region; extracellular space

Molecular Function:calcitonin receptor binding; identical protein binding; protein binding

Biological Process: activation of protein kinase activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; monocyte chemotaxis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of adenylate cyclase activity

NCBI Summary:This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
UniProt Code:P01258
NCBI GenInfo Identifier:322510018
NCBI Gene ID:796
NCBI Accession:P01258.2
UniProt Secondary Accession:P01258,Q13935, Q13937, Q52LX7, B7ZL39,
UniProt Related Accession:P01258,P06881
Molecular Weight:38.6kDa
NCBI Full Name:Calcitonin
NCBI Synonym Full Names:calcitonin related polypeptide alpha
NCBI Official Symbol:CALCA  
NCBI Official Synonym Symbols:CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I  
NCBI Protein Information:calcitonin; calcitonin gene-related peptide 1
UniProt Protein Name:Calcitonin
UniProt Synonym Protein Names:CalcitoninKatacalcinAlternative name(s):Calcitonin carboxyl-terminal peptide; CCP
UniProt Gene Name:CALCA  

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