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CALCA/CALCA Antibody (PACO05367)

SKU:
PACO05367
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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CALCA/CALCA Antibody (PACO05367)

The Calca Polyclonal Antibody (PACO05367) is a crucial tool for researchers studying the Calca gene, which encodes for the calcitonin-related polypeptide alpha. This polyclonal antibody, derived from rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.Calca is involved in several physiological processes, including bone metabolism, pain modulation, and neurotransmission. Dysregulation of Calca expression has been linked to conditions such as osteoporosis, chronic pain, and neurological disorders.

Therefore, understanding the role of Calca and its protein products is essential in developing targeted therapies for these diseases.By using the Calca Polyclonal Antibody, researchers can detect and analyze Calca protein expression in different cell types, providing valuable insights into its function and potential therapeutic targets. This antibody is a valuable tool for studies in the fields of bone biology, pain research, and neuroscience, offering new opportunities for advancing our understanding of Calca-related diseases and developing innovative treatments.

Antibody Name:CALCA/CALCA Antibody (PACO05367)
Antibody SKU:PACO05367
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:10000, IHC:1:100-1:300
Species Reactivity:Human
Immunogen:Synthesized peptide derived from the Internal region of human Calcitonin.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CALCA; CALC1; Calcitonin gene-related peptide 1; α-type CGRP; Calcitonin gene-related peptide I; CGRP-I; CALCA; CALC1; Calcitonin
UniProt Protein Function:CALCA iso3: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.2

Cellular Component: extracellular region; extracellular space

Molecular Function:calcitonin receptor binding; identical protein binding; protein binding

Biological Process: activation of protein kinase activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; monocyte chemotaxis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of adenylate cyclase activity

NCBI Summary:This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
UniProt Code:P06881
NCBI GenInfo Identifier:76880478
NCBI Gene ID:796
NCBI Accession:NP_001029125.1
UniProt Secondary Accession:P06881,Q93048, Q9UCP0,
UniProt Related Accession:P01258,P06881
Molecular Weight:15,466 Da
NCBI Full Name:calcitonin gene-related peptide 1 isoform alpha-CGRP preproprotein
NCBI Synonym Full Names:calcitonin related polypeptide alpha
NCBI Official Symbol:CALCA  
NCBI Official Synonym Symbols:CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I  
NCBI Protein Information:calcitonin; calcitonin gene-related peptide 1
UniProt Protein Name:Calcitonin gene-related peptide 1
UniProt Synonym Protein Names:Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I
Protein Family:Calcitonin
UniProt Gene Name:CALCA  
UniProt Entry Name:CALCA_HUMAN

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