CALCA Antibody (PACO07322)
- SKU:
- PACO07322
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CALCA Antibody (PACO07322)
The CALCA Polyclonal Antibody (PACO07322) is a valuable tool for researchers studying the CALCA gene, which encodes the calcitonin gene-related peptide (CGRP), a neuropeptide involved in a variety of physiological processes. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By binding specifically to the CALCA protein, this antibody enables the detection and analysis of CGRP in various cell types, making it ideal for research in neurology, cardiovascular biology, and pain management.
CGRP, a potent vasodilator and neurotransmitter, has been implicated in migraine pathophysiology, cardiovascular diseases, and inflammatory conditions. Targeting CGRP signaling has emerged as a promising strategy for developing novel therapies in these areas. The CALCA Polyclonal Antibody provides researchers with a reliable tool to investigate the role of CGRP in health and disease, ultimately contributing to the development of new treatment strategies.
| Antibody Name: | CALCA Antibody (PACO07322) |
| Antibody SKU: | PACO07322 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:10000-1:20000, WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide from human protein at AA range: 80-141 |
| Form: | Liquid |
| Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of Jurkat U937 Raji mouse-eye lysate, antibody was diluted at 1000. Secondary antibody was diluted at 1:20000. |
| Synonyms: | Calcitonin [Cleaved into: Calcitonin; Katacalcin (Calcitonin carboxyl-terminal peptide) (CCP) (PDN-21)] |
| UniProt Protein Function: | CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11p15.2 Cellular Component: extracellular region; extracellular space Molecular Function:calcitonin receptor binding; identical protein binding; protein binding Biological Process: activation of protein kinase activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; monocyte chemotaxis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of adenylate cyclase activity |
| NCBI Summary: | This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014] |
| UniProt Code: | P01258 |
| NCBI GenInfo Identifier: | 322510018 |
| NCBI Gene ID: | 796 |
| NCBI Accession: | P01258.2 |
| UniProt Secondary Accession: | P01258,Q13935, Q13937, Q52LX7, B7ZL39, |
| UniProt Related Accession: | P01258,P06881 |
| Molecular Weight: | 38.6kDa |
| NCBI Full Name: | Calcitonin |
| NCBI Synonym Full Names: | calcitonin related polypeptide alpha |
| NCBI Official Symbol: | CALCAÂ Â |
| NCBI Official Synonym Symbols: | CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-IÂ Â |
| NCBI Protein Information: | calcitonin; calcitonin gene-related peptide 1 |
| UniProt Protein Name: | Calcitonin |
| UniProt Synonym Protein Names: | CalcitoninKatacalcinAlternative name(s):Calcitonin carboxyl-terminal peptide; CCP |
| UniProt Gene Name: | CALCAÂ Â |
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