The CAGE1 Polyclonal Antibody (PACO19382) is a valuable tool for researchers studying CAGE1, a protein involved in regulating gene expression. This antibody, generated in rabbits, exhibits high sensitivity and specificity towards human samples, making it a reliable choice for Western blot applications. By binding to the CAGE1 protein, this antibody allows for the detection and analysis of CAGE1 in various cell types, making it ideal for studies in molecular biology and cancer research.CAGE1, also known as cancer/testis antigen 51, plays a critical role in controlling the expression of genes involved in cellular growth and proliferation.
Its dysregulation has been linked to various types of cancer, making it a promising target for therapeutic interventions. By better understanding the function of CAGE1, researchers can uncover new insights into the mechanisms driving cancer development and progression, ultimately leading to the development of more effective treatment strategies.
Antibody Name:
CAGE1 Antibody (PACO19382)
Antibody SKU:
PACO19382
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human CAGE1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19382(CAGE1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO19382(CAGE1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
CAGE1, also known as CT3; CT95; CTAG3; bA69L16.7, is a 639-amino acid, protein. It shares 76% sequence identity with a monkey homolog. RT-PCR analysis detected testis-specific expression among normal tissues and wide expression among various cancer tissues and cancer cell lines including those from cervical, melanoma, hepatic, renal, myeloma, and breast cancers. CTAG3 was overexpressed in cancer tissues compared with surrounding noncancerous tissues. Transfection experiments with a GFP-CTAG3 construct indicated a predominantly nuclear localization.
Synonyms:
cancer antigen 1
UniProt Protein Function:
CAGE1: 4 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 6p24.3Molecular Function: protein binding
