The CAGE1 Polyclonal Antibody (PACO19381) is a powerful tool for researchers studying the CAGE1 protein, a key player in cellular processes such as cell division and proliferation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the CAGE1 protein, this antibody facilitates the detection and analysis of CAGE1 in a variety of cell types, making it an invaluable tool for research in cell biology and cancer studies.
CAGE1 is a critical regulator of cell growth and division, making it an attractive target for research into cancer and other proliferative disorders. Understanding the function of CAGE1 can provide valuable insights into the mechanisms driving abnormal cell growth, with potential implications for the development of targeted therapies. By utilizing the CAGE1 Polyclonal Antibody, researchers can gain a deeper understanding of CAGE1's role in cellular processes and its potential as a therapeutic target.
Antibody Name:
CAGE1 Antibody (PACO19381)
Antibody SKU:
PACO19381
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:15-1:50
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human CAGE1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO19381(CAGE1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO19381(CAGE1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
CAGE1, also known as CT3; CT95; CTAG3; bA69L16.7, is a 639-amino acid, protein. It shares 76% sequence identity with a monkey homolog. RT-PCR analysis detected testis-specific expression among normal tissues and wide expression among various cancer tissues and cancer cell lines including those from cervical, melanoma, hepatic, renal, myeloma, and breast cancers. CTAG3 was overexpressed in cancer tissues compared with surrounding noncancerous tissues. Transfection experiments with a GFP-CTAG3 construct indicated a predominantly nuclear localization.
Synonyms:
cancer antigen 1
UniProt Protein Function:
CAGE1: 4 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 6p24.3Molecular Function: protein binding
