The CADM4 Polyclonal Antibody (PAC019380) is a vital tool for researchers studying CADM4, a cell adhesion molecule with important implications in neuronal development and synaptic function. This antibody, produced in rabbits, demonstrates strong reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CADM4 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential asset for studies in neuroscience and neurodevelopmental disorders.CADM4, also known as SynCAM4, plays a crucial role in mediating cell-cell adhesion in the nervous system, facilitating synaptic connectivity and neuronal communication. Dysregulation of CADM4 has been implicated in conditions such as autism spectrum disorders and schizophrenia, highlighting its significance in brain function and development.
Research on CADM4 provides valuable insights into the mechanisms underlying these disorders and holds promise for the development of novel therapeutic interventions targeting synaptic dysfunction.Overall, the CADM4 Polyclonal Antibody is a valuable tool for researchers exploring the role of CADM4 in neurobiology and neurodevelopment. Its high specificity and sensitivity make it ideal for investigating the functions of CADM4 in both normal and pathological conditions, paving the way for advancements in our understanding of brain development and neurological disorders.
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19380(CADM4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: RAW264.7 cells, mouse brain tissue, Primary antibody: PACO19380(CADM4 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19380(CADM4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
IGSF4C (immunoglobulin superfamily member 4C), also known as CADM4 (cell adhesion molecule 4), NECL4 or TSLL2, is a 388 amino acid, single-pass type I membrane protein that contains one Ig-like V-type domain and two Ig-like C2-type domains. Expressed in kidney, brain and prostate, IGSF4C exists as both a monomer and a homodimer and is thought to be involved in cell-cell adhesion, possibly playing a role in tumor suppression. Human IGSF4C shares 98% sequence identity with its mouse counterpart, suggesting a conserved role between species. The gene encoding IGSF4C maps to human chromosome 19, which is the genetic home for a number of immunoglobulin superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs)
Synonyms:
cell adhesion molecule 4
UniProt Protein Function:
Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.
