The Cadherin-5 Polyclonal Antibody (CAB0734) is a valuable tool for researchers studying Cadherin-5, a cell adhesion molecule involved in various cellular processes, including cell-cell adhesion and signaling. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications.Cadherin-5, also known as VE-Cadherin, is a critical component of endothelial cell adherens junctions and plays a key role in vascular integrity and barrier function. Dysregulation of Cadherin-5 has been implicated in various diseases, including cancer, cardiovascular disorders, and inflammatory conditions.
Research using this antibody can provide insights into the role of Cadherin-5 in these pathologies and may lead to the development of novel therapeutic strategies targeting Cadherin-5 pathways.Overall, the Cadherin-5 Polyclonal Antibody (CAB0734) is a valuable tool for investigators interested in exploring the functions of Cadherin-5 in both normal physiology and disease states. Its high specificity and sensitivity make it a reliable choice for studying Cadherin-5 expression and localization in various biological samples.
Product Name:
VE Cadherin Rabbit Polyclonal Antibody
SKU:
CAB0734
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 259-358 of human VE Cadherin (NP_001786.2).
Cell junction, Cell membrane, Single-pass type I membrane protein.
Calculated MW:
88kDa
Observed MW:
130kDa
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer.
Purification Method:
Affinity purification
Gene ID:
1003
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of HUVEC cells, using VE Cadherin antibody (CAB0734) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
