CDH4 Rabbit Polyclonal Antibody (CAB10557)
- SKU:
- CAB10557
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | CDH4 Rabbit Polyclonal Antibody |
SKU: | CAB10557 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 757-916 of human CDH4 (NP_001785.2). |
Sequence: | KRRE KERH TKQL LIDP EDDV RDNI LKYD EEGG GEED QDYD LSQL QQPE AMGH VPSK APGV RRVD ERPV GAEP QYPI RPMV PHPG DIGD FINE GLRA ADND PTAP PYDS LLVF DYEG SGST AGSV SSLN SSSS GDQD YDYL NDWG PRFK KLAD MYGG GEED |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 |
Synonyms: | CAD4; RCAD; R-CAD; CDH4 |
Positive Sample: | HepG2,Mouse brain,Mouse thymus,Rat brain,Rat skeletal muscle |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 100kDa |
Observed MW: | 100kDa/115kDa |
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 1002 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |