The Cadherin-16 Polyclonal Antibody (CAB7882) is a valuable tool for research involving Cadherin-16, a cell adhesion molecule implicated in various biological processes, including cell recognition and tissue organization. This antibody, produced through rabbit immunization, shows high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the Cadherin-16 protein, enabling accurate detection and analysis in a variety of cell types, making it ideal for studies in developmental biology and cancer research.
Cadherin-16, also known as K-cadherin, plays a crucial role in cell adhesion and tissue morphogenesis, contributing to processes such as cell sorting and tissue patterning. Its involvement in these fundamental biological processes makes it a key target for research into developmental disorders, cancer metastasis, and tissue regeneration. Understanding the functions and regulation of Cadherin-16 is essential for uncovering its implications in these contexts and developing targeted therapies or interventions based on its activity.
Product Name:
Cadherin 16 Rabbit Polyclonal Antibody
SKU:
CAB7882
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-230 of human Cadherin 16 (NP_004053.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
90kDa
Observed MW:
110kDa
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
1014
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cadherin 16 Rabbit pAb (CAB7882) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
